Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form is a genetic disorder that affects the adrenal glands. It is caused by a mutation in the CYP21A2 gene, which is responsible for producing the enzyme 21-hydroxylase. This enzyme is necessary for the production of cortisol and aldosterone, two hormones that are important for regulating the body's metabolism and stress response. Without enough of these hormones, the body produces too much androgen, a male sex hormone. This can lead to physical changes such as early puberty, abnormal genitalia, and infertility in both males and females.

The symptoms of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form, include:

-Early onset of puberty
-Ambiguous genitalia in newborns
-Enlarged clitoris
-Abnormal labia
-Abnormal pubic hair
-Deepening of the voice
-Acne
-Excess body hair
-Irregular menstrual periods
-Infertility

The cause of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form is a genetic mutation in the CYP21A2 gene. This gene provides instructions for making an enzyme called 21-hydroxylase, which is involved in the production of hormones such as cortisol and aldosterone. Mutations in this gene reduce or eliminate the activity of 21-hydroxylase, leading to a buildup of hormones that cause the signs and symptoms of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form.

1. Hydrocortisone: Hydrocortisone is a steroid hormone that is used to replace the cortisol that is deficient in people with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

2. Fludrocortisone: Fludrocortisone is a synthetic mineralocorticoid that is used to replace the aldosterone that is deficient in people with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

3. Salt supplementation: Salt supplementation is used to help maintain normal electrolyte balance in people with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

4. Antiandrogens: Antiandrogens are medications that are used to block the effects of androgens in people with classic congenital

1. Genetic mutation in the CYP21A2 gene
2. Family history of the disorder
3. Female gender
4. Premature adrenarche
5. Low birth weight
6. Low cortisol levels
7. High levels of androgens
8. Abnormal genitalia in newborns
9. Abnormal development of the adrenal glands
10. Abnormal development of the reproductive organs

Yes, there is a cure for classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form. Treatment typically involves lifelong hormone replacement therapy with glucocorticoids and mineralocorticoids, as well as androgen replacement therapy. In some cases, surgery may be necessary to correct any physical abnormalities. Additionally, lifestyle modifications such as a healthy diet and regular exercise can help to manage symptoms.