Class I glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder caused by a mutation in the G6PD gene. This gene provides instructions for making an enzyme called glucose-6-phosphate dehydrogenase, which helps red blood cells (RBCs) use glucose for energy. People with Class I G6PD deficiency have a severe form of the disorder, which can cause anemia and other serious health problems. Symptoms of Class I G6PD deficiency can include jaundice, fatigue, dark urine, and an enlarged spleen. Treatment typically involves avoiding certain medications and foods that can trigger a reaction.

The symptoms of Class I glucose-6-phosphate dehydrogenase (G6PD) deficiency can vary from person to person, but the most common symptoms include:

-Anemia (low red blood cell count)
-Jaundice (yellowing of the skin and eyes)
-Dark urine
-Fatigue
-Shortness of breath
-Paleness
-Enlarged spleen
-Abdominal pain
-Fever
-Nausea
-Vomiting
-Headache
-Rash
-Blisters on the skin

Class I glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder caused by mutations in the G6PD gene. These mutations lead to a decrease in the activity of the enzyme, which is responsible for helping red blood cells to function normally. The most common cause of G6PD deficiency is a mutation in the G6PD gene on the X chromosome. Other causes include mutations in other genes, such as the G6PD A- gene, and environmental factors, such as certain medications, infections, and dietary deficiencies.

1. Avoiding drugs that can cause hemolysis, such as sulfonamides, antimalarials, and certain antibiotics.

2. Taking folic acid supplements to help reduce the risk of anemia.

3. Taking iron supplements to help replenish red blood cells.

4. Taking vitamin B12 supplements to help reduce the risk of anemia.

5. Taking antioxidants, such as vitamin E, to help reduce oxidative stress.

6. Taking glucose-6-phosphate dehydrogenase enzyme replacement therapy.

7. Taking corticosteroids to help reduce inflammation.

8. Taking anticoagulants to help reduce the risk of blood clots.

1. Ethnicity: Class I G6PD deficiency is most common in people of African, Mediterranean, and Southeast Asian descent.

2. Sex: Males are more likely to be affected than females.

3. Age: Infants and young children are more likely to be affected than adults.

4. Exposure to certain medications: Certain medications, such as antimalarials, sulfonamides, and nitrofurantoin, can trigger a G6PD deficiency.

5. Exposure to certain foods: Eating fava beans can trigger a G6PD deficiency.

Yes, there are treatments available for Class I glucose-6-phosphate dehydrogenase deficiency. Treatment typically involves avoiding certain medications that can cause a buildup of toxins in the body, such as certain antibiotics, antimalarial drugs, and sulfonamides. Additionally, medications such as riboflavin, N-acetylcysteine, and deferoxamine may be prescribed to help reduce the buildup of toxins. In some cases, a blood transfusion may be necessary.