Chronic myeloid leukemia (CML) is a type of cancer that affects the blood and bone marrow. It is caused by a genetic mutation in the bone marrow cells that leads to the overproduction of white blood cells. CML is a slow-growing cancer that can be managed with medication and lifestyle changes. Symptoms of CML include fatigue, fever, night sweats, weight loss, and an enlarged spleen. Treatment options include chemotherapy, targeted therapy, and stem cell transplant.

The most common symptoms of chronic myeloid leukemia (CML) include:

-Fatigue
-Weight loss
-Fever
-Night sweats
-Loss of appetite
-Enlarged spleen
-Bone pain
-Easy bruising or bleeding
-Shortness of breath
-Pale skin

The exact cause of chronic myeloid leukemia (CML) is unknown. However, it is believed to be caused by a genetic mutation in the bone marrow cells that produce white blood cells. This mutation causes the bone marrow to produce too many white blood cells, which can lead to CML. Other possible causes of CML include exposure to certain chemicals, radiation, and viruses.

1. Tyrosine Kinase Inhibitors (TKIs): These drugs target and block the activity of the BCR-ABL protein, which is responsible for the abnormal growth of CML cells. Examples of TKIs include imatinib (Gleevec), dasatinib (Sprycel), nilotinib (Tasigna), bosutinib (Bosulif), and ponatinib (Iclusig).

2. Interferon-alpha: This is a type of protein that helps the body fight infections and cancer. It is used to treat CML in combination with TKIs.

3. Stem Cell Transplant: This is a procedure in which healthy stem cells are transplanted into the body to replace the abnormal CML cells.

4. Chemotherapy:

1. Age: Most cases of CML occur in people over the age of 55.
2. Gender: Men are more likely to develop CML than women.
3. Exposure to radiation: People who have been exposed to high levels of radiation, such as those who have had radiation therapy for another cancer, have an increased risk of developing CML.
4. Family history: People with a family history of CML are more likely to develop the disease.
5. Certain genetic conditions: People with certain genetic conditions, such as Down syndrome, are more likely to develop CML.
6. Certain medications: People who take certain medications, such as certain chemotherapy drugs, are at an increased risk of developing CML.

Yes, there are several treatments available for Chronic myeloid leukemia (CML). These include targeted therapies such as tyrosine kinase inhibitors (TKIs) and interferon-alpha, as well as chemotherapy, stem cell transplantation, and radiation therapy. Your doctor will be able to discuss the best treatment option for you.