1. Genetic predisposition: Certain genetic mutations, such as those in the SH2D1A gene, have been linked to an increased risk of developing Chronic Lymphoproliferative Disorder of Natural Killer Cells (CLPD-NK).
2. Age: CLPD-NK is more common in adults over the age of 40.
3. Gender: CLPD-NK is more common in males than females.
4. Immunodeficiency: People with weakened immune systems, such as those with HIV/AIDS, are at an increased risk of developing CLPD-NK.
5. Exposure to certain chemicals: Exposure to certain chemicals, such as benzene, may increase the risk of developing CLPD-NK.