Chronic intervillositis of unknown etiology (CIUE) is a rare condition that affects the placenta, the organ that connects a mother and her unborn baby. It is characterized by inflammation of the intervillous space, the area between the maternal and fetal blood vessels in the placenta. The cause of CIUE is unknown, but it is thought to be an autoimmune disorder. Symptoms of CIUE include preterm labor, intrauterine growth restriction, and fetal death. Treatment typically involves corticosteroids and other immunosuppressive medications.

The symptoms of Chronic intervillositis of unknown etiology (CIUE) vary from person to person, but may include:

- Abdominal pain
- Diarrhea
- Weight loss
- Fatigue
- Fever
- Nausea
- Vomiting
- Abnormal vaginal bleeding
- Abnormal uterine bleeding
- Infertility
- Miscarriage
- Preterm labor
- Intrauterine growth restriction
- Placental abruption
- Fetal death

The exact cause of chronic intervillositis of unknown etiology (CIE) is unknown. However, some potential causes that have been suggested include:

1. Autoimmune disorders
2. Genetic predisposition
3. Infections
4. Environmental factors
5. Drug reactions
6. Hormonal imbalances
7. Nutritional deficiencies
8. Exposure to toxins

1. Corticosteroids: Corticosteroids are the most commonly used treatment for chronic intervillositis of unknown etiology. They can reduce inflammation and help to control symptoms.

2. Immunosuppressants: Immunosuppressants such as azathioprine, cyclosporine, and mycophenolate mofetil can be used to reduce inflammation and help to control symptoms.

3. Antibiotics: Antibiotics may be prescribed to treat any underlying infection that may be contributing to the condition.

4. Anti-inflammatory medications: Non-steroidal anti-inflammatory medications such as ibuprofen and naproxen can help to reduce inflammation and pain.

5. Diet and lifestyle changes: Eating a healthy diet and avoiding foods that may trigger inflammation can help to reduce symptoms.

1. Age: Chronic intervillositis of unknown etiology is more common in women aged 20-40.

2. Ethnicity: African-American women are more likely to be affected by this condition.

3. Family history: Women with a family history of chronic intervillositis of unknown etiology are more likely to develop the condition.

4. Smoking: Women who smoke are more likely to develop chronic intervillositis of unknown etiology.

5. Obesity: Women who are obese are more likely to develop chronic intervillositis of unknown etiology.

6. Stress: Women who are under a lot of stress are more likely to develop chronic intervillositis of unknown etiology.

There is no known cure for chronic intervillositis of unknown etiology. Treatment typically involves medications to reduce inflammation and pain, such as corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and immunosuppressants. Other treatments may include lifestyle modifications, such as avoiding certain foods or activities that may trigger symptoms.