The exact cause of Childhood-onset benign chorea with striatal involvement is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Possible causes include:
1. Genetic mutations: Certain genetic mutations have been linked to this condition, including those in the genes SLC2A1, SLC6A3, and SLC6A4.
2. Infections: Certain infections, such as those caused by the Epstein-Barr virus, may be linked to this condition.
3. Autoimmune disorders: Autoimmune disorders, such as systemic lupus erythematosus, may be linked to this condition.
4. Environmental factors: Exposure to certain environmental toxins, such as lead, may be linked to this condition.