Charcot-Marie-Tooth disease type 4H (CMT4H) is a rare, inherited neurological disorder that affects the peripheral nerves. It is characterized by progressive muscle weakness and wasting, as well as sensory loss in the feet and hands. CMT4H is caused by mutations in the SH3TC2 gene, which is responsible for producing a protein that helps maintain the structure of the peripheral nerves. Symptoms of CMT4H usually begin in childhood or adolescence and can include difficulty walking, frequent falls, and muscle cramps. Treatment for CMT4H is supportive and may include physical therapy, occupational therapy, and orthopedic devices.