Charcot-Marie-Tooth disease type 4E (CMT4E) is a rare, inherited neurological disorder that affects the peripheral nerves. It is characterized by progressive muscle weakness and wasting, as well as sensory loss in the feet and hands. CMT4E is caused by mutations in the SH3TC2 gene, which is responsible for producing a protein that helps maintain the structure of the peripheral nerves. Symptoms of CMT4E usually begin in childhood and can include difficulty walking, frequent falls, and difficulty with fine motor skills. Treatment for CMT4E is supportive and may include physical therapy, occupational therapy, and orthopedic devices.