1. Activation of CAR T cells: CAR T cells are engineered to recognize and attack cancer cells. When they encounter their target, they become activated and release large amounts of cytokines, which can cause a systemic inflammatory response.
2. Overactivation of CAR T cells: In some cases, CAR T cells can become overactivated and release too many cytokines, leading to a cytokine storm.
3. Inadequate CAR T cell control: If the CAR T cells are not adequately controlled, they can become overactivated and release too many cytokines.
4. Inadequate CAR T cell expansion: If the CAR T cells do not expand adequately, they may not be able to effectively target the cancer cells, leading to an overactivation of the CAR T cells and a cytokine storm.
5. Inadequate CAR