Camurati-Engelmann Disease (CED) is a rare genetic disorder that affects the bones. It is caused by a mutation in the gene that produces the protein TGFB1, which is involved in the formation of bone and cartilage. Symptoms of CED include bone pain, muscle weakness, and skeletal deformities. It is a progressive disorder, meaning that symptoms worsen over time. Treatment typically involves medications to reduce pain and physical therapy to help maintain mobility.