Calpain-3-related limb-girdle muscular dystrophy D4 (LGMD2A) is a rare, inherited neuromuscular disorder caused by mutations in the CAPN3 gene. It is characterized by progressive muscle weakness and wasting (atrophy) of the muscles of the hips, shoulders, and upper arms. Symptoms usually begin in childhood or adolescence and may include difficulty walking, climbing stairs, and lifting objects. Other symptoms may include muscle cramps, joint contractures, and difficulty swallowing. There is currently no cure for LGMD2A, but physical therapy, occupational therapy, and medications may help to manage symptoms.