Buerger's disease (also known as thromboangiitis obliterans) is a rare inflammatory disease of the blood vessels that primarily affects the arteries and veins in the arms and legs. It is characterized by inflammation and clotting of the blood vessels, leading to reduced blood flow and tissue damage. Symptoms include pain, numbness, and discoloration of the affected area. The cause of Buerger's disease is unknown, but it is believed to be related to smoking. Treatment typically involves quitting smoking, medications to reduce inflammation, and surgery to remove the affected blood vessels.