Brain malformation-congenital heart disease-postaxial polydactyly syndrome is a rare genetic disorder characterized by the presence of an extra finger or toe on the side of the hand or foot furthest from the thumb or big toe, as well as malformations of the brain and heart. It is caused by a mutation in the GLI3 gene. Symptoms may include developmental delays, intellectual disability, seizures, and vision and hearing problems. Treatment typically involves surgery to remove the extra digit, as well as medications and therapies to address the other symptoms.

The symptoms of Brain malformation-congenital heart disease-postaxial polydactyly syndrome include:

-Developmental delay
-Seizures
-Cognitive impairment
-Feeding difficulties
-Growth retardation
-Hearing loss
-Vision problems
-Heart defects
-Abnormalities of the hands and feet, including extra fingers or toes (polydactyly)
-Abnormalities of the face, including a wide-set eyes, a flat nasal bridge, and a small lower jaw
-Abnormalities of the skull, including a Small head size (microcephaly) and an abnormally shaped head (dolichocephaly)
-Abnormalities of the spine, including Scoliosis and kyphosis

1. Genetic mutations: Certain genetic mutations can cause malformations of the brain, such as chromosomal abnormalities, single gene defects, and microdeletions.

2. Environmental factors: Exposure to certain environmental toxins, such as alcohol, drugs, and radiation, can cause malformations of the brain.

3. Infections: Infections during pregnancy, such as rubella, cytomegalovirus, and toxoplasmosis, can cause malformations of the brain.

4. Nutritional deficiencies: Deficiencies in certain vitamins and minerals, such as folic acid, can cause malformations of the brain.

5. Congenital heart disease: Congenital heart disease can cause malformations of the brain due to decreased oxygen supply to the brain.

6. Postaxial poly

Treatment for Brain malformation-congenital heart disease-postaxial polydactyly syndrome will depend on the severity of the individual's condition. Treatment may include:

1. Surgery to correct the heart defect and/or malformation.

2. Medication to control seizures or other symptoms.

3. Physical therapy to help with motor skills and coordination.

4. Occupational therapy to help with daily activities.

5. Speech therapy to help with communication.

6. Genetic counseling to help families understand the condition and its implications.

7. Psychological counseling to help with emotional issues.

1. Maternal diabetes
2. Maternal alcohol use
3. Maternal smoking
4. Maternal age
5. Maternal obesity
6. Maternal exposure to certain medications
7. Maternal exposure to certain environmental toxins
8. Genetic factors
9. Family history of the condition
10. Low birth weight

Unfortunately, there is no cure for Brain malformation-congenital heart disease-postaxial polydactyly syndrome. However, there are medications that can help manage the symptoms associated with the condition. These medications may include diuretics, ACE inhibitors, beta blockers, and anticoagulants. Additionally, surgery may be necessary to repair any structural defects in the heart or other organs.