Brachydactyly-syndactyly, Zhao type is a rare genetic disorder characterized by short fingers and toes (brachydactyly) and webbing of the fingers and toes (syndactyly). It is caused by a mutation in the HOXD13 gene and is inherited in an autosomal dominant pattern. Symptoms may include short fingers and toes, webbing of the fingers and toes, and a wide gap between the first and second toes. Treatment is typically supportive and may include physical therapy, splinting, and surgery to correct the webbing.

The symptoms of Brachydactyly-syndactyly, Zhao type include:

-Shortening of the fingers and toes
-Webbing of the fingers and toes
-Abnormal nail development
-Abnormal joint development
-Abnormal bone development
-Abnormal skin creases on the palms and soles
-Abnormal muscle development
-Abnormal tendon development
-Abnormal ligament development
-Abnormal cartilage development
-Abnormal facial features
-Abnormal skull shape
-Abnormal ear shape
-Abnormal eye shape
-Abnormal teeth shape
-Abnormal hair growth
-Abnormal sweat gland development
-Abnormal kidney development
-Abnormal heart development
-Abnormal genital development
-Abnormal hearing loss
-Abnormal vision loss
-Abnormal speech development

Brachydactyly-syndactyly, Zhao type is a rare genetic disorder caused by mutations in the HOXD13 gene. This gene is responsible for the development of the hands and feet. Mutations in this gene can cause the fingers and toes to be abnormally short and fused together.

1. Surgery: Surgery is the most common treatment for Brachydactyly-syndactyly, Zhao type. This involves separating the fused digits and reconstructing the affected fingers and toes.

2. Physical Therapy: Physical therapy can help improve range of motion and strength in the affected digits.

3. Splinting: Splinting can help maintain the position of the digits and prevent further fusion.

4. Orthotics: Orthotics can be used to help support the affected digits and improve function.

5. Occupational Therapy: Occupational therapy can help improve fine motor skills and dexterity.

1. Genetic mutation in the HOXD13 gene
2. Family history of Brachydactyly-syndactyly, Zhao type
3. Female gender
4. Advanced maternal age
5. Exposure to certain environmental toxins or medications during pregnancy

At this time, there is no known cure for Brachydactyly-syndactyly, Zhao type. However, there are treatments available to help manage the symptoms. These include physical therapy, occupational therapy, and surgery to correct any deformities. Medications may also be prescribed to help manage pain and swelling.