About BOR syndrome

What is BOR syndrome?

BOR syndrome, also known as Brachial Plexus Birth Palsy, is a condition that occurs when the nerves of the brachial plexus are damaged during childbirth. This can cause weakness or paralysis of the arm, shoulder, and hand on the affected side. Symptoms may include decreased movement of the arm, decreased sensation in the arm, and decreased grip strength. Treatment may include physical therapy, occupational therapy, and surgery.

What are the symptoms of BOR syndrome?

The symptoms of BOR syndrome vary depending on the severity of the condition, but may include:

-Developmental delays
-Intellectual disability
-Growth delays
-Feeding difficulties
-Hearing loss
-Vision problems
-Heart defects
-Kidney problems
-Abnormal facial features
-Cleft lip or palate
-Joint contractures
-Muscle weakness
-Skeletal abnormalities
-Skin abnormalities

What are the causes of BOR syndrome?

BOR (Bilateral Optic Atrophy with Retinal Pigmentary Changes) Syndrome is a rare genetic disorder caused by mutations in the OPA1 gene. This gene is responsible for the production of a protein that helps maintain the structure and function of mitochondria, the energy-producing organelles in cells. Mutations in the OPA1 gene can lead to a decrease in the production of this protein, resulting in the death of cells in the optic nerve and retina, leading to vision loss. Other symptoms of BOR Syndrome include hearing loss, developmental delays, and muscle weakness.

What are the treatments for BOR syndrome?

The primary treatment for BOR syndrome is physical therapy. Physical therapy can help to improve range of motion, strength, and coordination. Other treatments may include bracing, splinting, and orthotics. Surgery may be recommended in some cases to correct any underlying structural issues. Additionally, medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) may be prescribed to reduce pain and inflammation.

What are the risk factors for BOR syndrome?

1. Premature birth
2. Low birth weight
3. Maternal smoking during pregnancy
4. Maternal alcohol consumption during pregnancy
5. Maternal drug use during pregnancy
6. Maternal diabetes
7. Maternal hypertension
8. Maternal obesity
9. Maternal age over 35
10. Male gender
11. Family history of BOR syndrome

Is there a cure/medications for BOR syndrome?

At this time, there is no known cure for BOR syndrome. However, there are medications that can help manage the symptoms of BOR syndrome. These medications include anticonvulsants, muscle relaxants, and antidepressants. Additionally, physical therapy and occupational therapy can help improve mobility and reduce pain.