Bohring-Opitz Syndrome (BOS) is a rare genetic disorder that affects the development of the brain, spinal cord, and other organs. It is characterized by severe intellectual disability, seizures, and physical abnormalities. Affected individuals may also have distinctive facial features, including a broad forehead, wide-set eyes, and a small chin. Other features may include feeding difficulties, poor muscle tone, and joint contractures. The exact cause of BOS is unknown, but it is believed to be caused by a mutation in the RAB23 gene.