The treatments for Best Disease vary depending on the severity of the condition. Generally, treatments may include medications to reduce inflammation, physical therapy, lifestyle changes, and surgery. Medications may include corticosteroids, immunosuppressants, and biologic agents. Physical therapy may include exercises to improve mobility and strength, as well as assistive devices to help with daily activities. Lifestyle changes may include quitting smoking, eating a healthy diet, and getting regular exercise. Surgery may be necessary in some cases to correct vision problems or to remove damaged tissue.