The treatments for Bernard-Soulier Syndrome vary depending on the severity of the condition. Generally, treatment focuses on managing the symptoms and preventing complications. This may include medications to reduce the risk of bleeding, such as desmopressin, antifibrinolytic agents, and platelet transfusions. In some cases, surgery may be necessary to repair damaged blood vessels or to remove a spleen. In addition, regular monitoring of platelet counts and other blood tests is important to ensure that the condition is being managed properly.