About Benign recurrent intrahepatic cholestasis type 1
What is Benign recurrent intrahepatic cholestasis type 1?
Benign recurrent intrahepatic cholestasis type 1 (BRIC1) is a rare inherited disorder of the liver that causes episodes of jaundice (yellowing of the skin and eyes) and itching. It is caused by a mutation in the ABCB11 gene, which is responsible for transporting bile acids out of the liver. During episodes of BRIC1, bile acids accumulate in the liver, leading to inflammation and damage. Symptoms usually begin in childhood and can last for weeks or months. Treatment typically involves medications to reduce itching and inflammation, as well as dietary changes to reduce the amount of bile acids in the body.
What are the symptoms of Benign recurrent intrahepatic cholestasis type 1?
What are the causes of Benign recurrent intrahepatic cholestasis type 1?
Benign recurrent intrahepatic cholestasis type 1 (BRIC1) is an inherited disorder caused by mutations in the ABCB11 gene. This gene provides instructions for making a protein that helps transport bile acids out of the liver. Mutations in this gene lead to an accumulation of bile acids in the liver, which can cause inflammation and damage to the organ. Other causes of BRIC1 include certain medications, infections, and autoimmune disorders.
What are the treatments for Benign recurrent intrahepatic cholestasis type 1?
The primary treatment for Benign recurrent intrahepatic cholestasis type 1 (BRIC1) is supportive care. This includes lifestyle modifications such as avoiding alcohol and certain medications, as well as dietary changes to reduce fat and cholesterol intake. Additionally, medications such as ursodeoxycholic acid (UDCA) and rifampicin may be prescribed to reduce symptoms and improve liver function. In some cases, liver transplantation may be necessary.
What are the risk factors for Benign recurrent intrahepatic cholestasis type 1?
The risk factors for Benign recurrent intrahepatic cholestasis type 1 (BRIC1) include:
1. Female gender
2. Age (usually occurs in adults between the ages of 20 and 40)
3. Family history of BRIC1
4. Certain medications, such as antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs
5. Pregnancy
6. Alcohol consumption
7. Obesity
8. Liver disease
9. Gallstones
Is there a cure/medications for Benign recurrent intrahepatic cholestasis type 1?
At this time, there is no known cure for Benign recurrent intrahepatic cholestasis type 1 (BRIC1). However, medications such as ursodeoxycholic acid (UDCA) and rifampicin may be used to help manage symptoms and reduce the risk of complications. Additionally, lifestyle modifications such as avoiding alcohol and certain medications, eating a healthy diet, and exercising regularly may help to reduce symptoms.