Beckwith-Wiedemann syndrome (BWS) is a genetic disorder caused by a duplication of a small region of chromosome 11, known as 11p15. This duplication can be inherited from a parent or can occur spontaneously. The exact cause of the duplication is unknown, but it is believed to be due to errors in the way the chromosomes divide during cell division. Possible causes of the duplication include:
1. Chromosomal nondisjunction: This is when the chromosomes fail to separate properly during cell division, resulting in an extra copy of the chromosome.
2. Uniparental disomy: This is when both copies of a chromosome come from the same parent, instead of one from each parent.
3. Imprinting defects: This is when the genetic material from one parent is not expressed properly, resulting in an