Autosomal spastic paraplegia type 30 (SPG30) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG30 gene, which is located on chromosome 17. Symptoms usually begin in childhood or adolescence and may include difficulty walking, muscle spasms, and difficulty with balance and coordination. In some cases, the disorder can also affect the arms and hands. There is currently no cure for SPG30, but physical therapy and medications can help manage symptoms.