Autosomal recessive spastic paraplegia type 64 (SPG64) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SLC33A1 gene, which is responsible for the production of a protein called acetyl-CoA synthetase. Symptoms typically begin in childhood or adolescence and worsen over time. Affected individuals may experience difficulty walking, balance problems, and muscle spasms. There is currently no cure for SPG64, but physical therapy and medications may help to manage symptoms.

The symptoms of Autosomal recessive spastic paraplegia type 64 (SPG64) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 64 (SPG64) is caused by mutations in the SLC33A1 gene. This gene provides instructions for making a protein that is involved in transporting molecules into and out of cells. Mutations in this gene lead to a decrease in the amount of functional SLC33A1 protein, which disrupts the transport of molecules into and out of cells and causes the signs and symptoms of SPG64.

Currently, there is no known cure for Autosomal recessive spastic paraplegia type 64. Treatment focuses on managing the symptoms and preventing further complications. This may include physical therapy, occupational therapy, speech therapy, and medications to reduce muscle spasms and pain. Assistive devices such as wheelchairs, walkers, and braces may also be used to help with mobility. In some cases, surgery may be recommended to help improve mobility and reduce pain.

1. Having a family history of Autosomal recessive spastic paraplegia type 64.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SPG64 gene.
4. Being exposed to certain environmental factors.
5. Having a weakened immune system.

At this time, there is no known cure or medications for Autosomal recessive spastic paraplegia type 64. Treatment focuses on managing the symptoms and preventing complications. This may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to reduce spasticity.