Autosomal recessive spastic paraplegia type 45 (SPG45) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG45 gene, which is located on chromosome 17. Symptoms usually begin in childhood or adolescence and may include difficulty walking, difficulty with balance, and muscle spasms. In some cases, the disorder may also affect the arms and hands. There is currently no cure for SPG45, but physical therapy and medications may help to manage symptoms.