Autosomal recessive spastic paraplegia type 32 (SPG32) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG11 gene, which is involved in the formation of the myelin sheath, a protective coating around nerve cells. Symptoms usually begin in childhood and worsen over time, leading to difficulty walking and other mobility issues. Other symptoms may include bladder and bowel problems, muscle wasting, and cognitive impairment. Treatment is supportive and may include physical therapy, medications, and assistive devices.

The symptoms of Autosomal recessive spastic paraplegia type 32 (SPG32) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 32 (SPG32) is caused by mutations in the KIF5A gene. This gene provides instructions for making a protein called kinesin family member 5A, which is involved in the transport of materials within cells. Mutations in the KIF5A gene lead to the production of an abnormally short, nonfunctional version of the kinesin family member 5A protein. This protein is thought to be involved in the development and maintenance of the long fibers that connect nerve cells in the brain and spinal cord (axons). Without functional kinesin family member 5A protein, the axons cannot form properly, leading to the signs and symptoms of SPG32.

1. Having a family history of Autosomal recessive spastic paraplegia type 32.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SLC33A1 gene.
4. Being exposed to certain environmental factors.
5. Having a weakened immune system.

At this time, there is no known cure or medications for Autosomal recessive spastic paraplegia type 32. Treatment focuses on managing the symptoms and preventing complications. This may include physical therapy, occupational therapy, speech therapy, orthopedic devices, and medications to reduce spasticity.