Autosomal recessive spastic paraplegia type 28 (SPG28) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the KIF5A gene, which is responsible for the production of a protein that helps transport materials within cells. Symptoms typically begin in childhood or adolescence and may include difficulty walking, muscle stiffness, and weakness in the legs. In some cases, the disorder may also cause intellectual disability, seizures, and vision problems. Treatment is symptomatic and may include physical therapy, medications, and assistive devices.