Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG25 gene, which is responsible for producing a protein called paraplegin. Symptoms usually begin in childhood or adolescence and may include difficulty walking, muscle stiffness, and weakness in the legs. In some cases, the disorder can also affect the arms and hands. There is currently no cure for SPG25, but physical therapy and medications can help manage symptoms.