Autosomal recessive spastic paraplegia type 11 (SPG11) is a rare, inherited neurological disorder characterized by progressive muscle weakness and stiffness (spasticity) in the legs. It is caused by mutations in the SPG11 gene, which is responsible for producing a protein called paraplegin. Symptoms usually begin in childhood or adolescence and may include difficulty walking, muscle stiffness, and weakness in the legs. In some cases, the disorder can also affect the arms, hands, and face.

The symptoms of Autosomal recessive spastic paraplegia type 11 (SPG11) vary from person to person, but may include:

- Muscle Weakness and Stiffness in the legs
- Difficulty walking, running, or climbing stairs
- Loss of balance and coordination
- Abnormal gait
- Urinary and/or fecal incontinence
- Muscle spasms
- Pain in the legs
- Fatigue
- Difficulty with fine motor skills
- Speech and language difficulties
- Cognitive impairment

Autosomal recessive spastic paraplegia type 11 (SPG11) is caused by mutations in the KIF5A gene. Mutations in this gene lead to a decrease in the production of the KIF5A protein, which is involved in the transport of molecules within cells. This decrease in the production of the KIF5A protein leads to the development of SPG11.

1. Physical therapy: Physical therapy can help improve muscle strength, flexibility, and coordination. It can also help reduce spasticity and improve balance and gait.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce spasticity and improve muscle control.

3. Surgery: Surgery may be recommended to help improve mobility and reduce spasticity.

4. Assistive devices: Assistive devices such as walkers, canes, and wheelchairs can help improve mobility and independence.

5. Orthotics: Orthotics such as braces and splints can help improve posture and reduce spasticity.

6. Nutritional supplements: Nutritional supplements such as omega-3 fatty acids, vitamin B12, and vitamin E may help improve muscle strength

1. Having a family history of Autosomal recessive spastic paraplegia type 11.
2. Being of Ashkenazi Jewish descent.
3. Having a mutation in the SPG11 gene.
4. Being exposed to certain environmental toxins.
5. Having a weakened immune system.

At this time, there is no known cure for Autosomal recessive spastic paraplegia type 11. However, there are medications that can help manage the symptoms of the condition. These medications include muscle relaxants, antispasmodics, and medications to help with bladder control. Physical therapy and occupational therapy can also help to improve mobility and quality of life.