Autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome (ARIS) is a rare genetic disorder characterized by a combination of neurological and ocular symptoms. It is caused by mutations in the SLC25A12 gene, which is responsible for the production of a protein involved in the transport of mitochondrial metabolites. Symptoms of ARIS include progressive leukoencephalopathy (white matter disease of the brain), ischemic stroke, and retinitis pigmentosa (a degenerative eye disorder). Other symptoms may include seizures, cognitive impairment, and movement disorders. Treatment is supportive and may include physical therapy, occupational therapy, and speech therapy.