Autosomal recessive generalized epidermolysis bullosa simplex (AR-G-EBS) is a rare genetic disorder that affects the skin. It is caused by mutations in the KRT5 or KRT14 genes, which are responsible for producing proteins that help form the skin's outer layer. People with AR-G-EBS have fragile skin that blisters and tears easily, even with minimal trauma. Blisters can form anywhere on the body, including the hands, feet, and face. Other symptoms may include scarring, skin infections, and nail abnormalities. Treatment for AR-G-EBS is focused on managing symptoms and preventing complications.