Autosomal recessive faciodigitogenital syndrome (FDG) is a rare genetic disorder that affects the development of the face, digits, and genitals. It is caused by a mutation in the gene that codes for the enzyme dihydropyrimidine dehydrogenase (DPD). Symptoms of FDG include facial dysmorphism, syndactyly (webbed fingers and toes), and genital malformations. Other features may include intellectual disability, growth retardation, and hearing loss. Treatment is supportive and may include physical and occupational therapy, speech therapy, and genetic counseling.