Autosomal recessive cerebellar ataxia-movement disorder syndrome is a rare genetic disorder that affects the cerebellum, a part of the brain that controls movement. It is characterized by progressive difficulty with coordination, balance, and speech. Symptoms may include difficulty walking, clumsiness, tremors, and slurred speech. The disorder is caused by mutations in certain genes and is inherited in an autosomal recessive pattern, meaning that both copies of the gene must be mutated for a person to be affected.

The symptoms of Autosomal recessive cerebellar ataxia-movement disorder syndrome can vary from person to person, but generally include:

• Uncoordinated movements, such as difficulty walking, clumsiness, and poor balance

• Slurred speech

• Difficulty with fine motor skills, such as writing or buttoning a shirt

• Muscle weakness

• Abnormal eye movements

• Tremors

• Cognitive impairment

• Seizures

• Hearing loss

• Vision problems

• Fatigue

• Difficulty swallowing

Autosomal recessive cerebellar ataxia-movement disorder syndrome is caused by mutations in a variety of genes, including:

1. SLC17A5
2. SLC1A3
3. SLC6A8
4. SLC25A12
5. ATP1A3
6. PNKP
7. APTX
8. TUBB4A
9. VLDLR
10. CACNA1A
11. FRMD7
12. DARS2
13. SPTBN2
14. KIF1A
15. SETX
16. CACNA1G
17. PPP2R2B
18. TAF1
19. TUBB2B
20. TUBB3

1. Physical therapy: Physical therapy can help improve balance, coordination, and strength.

2. Occupational therapy: Occupational therapy can help with activities of daily living, such as dressing, eating, and bathing.

3. Speech therapy: Speech therapy can help with communication and swallowing difficulties.

4. Medications: Medications can help reduce symptoms such as tremor, muscle spasms, and difficulty walking.

5. Surgery: Surgery may be recommended in some cases to help improve mobility.

6. Assistive devices: Assistive devices such as walkers, canes, and wheelchairs can help improve mobility.

1. Family history of Autosomal recessive cerebellar ataxia-movement disorder syndrome
2. Genetic mutations in the ATXN1, ATXN2, ATXN3, and ATXN7 genes
3. Exposure to certain environmental toxins
4. Certain viral infections
5. Certain medications
6. Alcohol consumption
7. Vitamin B12 deficiency
8. Vitamin E deficiency
9. Low levels of folate
10. Low levels of copper

At this time, there is no cure for Autosomal recessive cerebellar ataxia-movement disorder syndrome. However, there are medications that can help manage the symptoms of the disorder. These medications include muscle relaxants, anticonvulsants, and medications to help with balance and coordination. Additionally, physical and occupational therapy can help improve coordination and balance.