Autosomal dominant proximal renal tubular acidosis (ADRTA) is a rare inherited disorder that affects the kidneys. It is caused by a mutation in the SLC4A1 gene, which is responsible for the production of a protein called sodium bicarbonate cotransporter (NBC). This protein helps the kidneys regulate the acid-base balance in the body. People with ADRTA have a defect in the NBC protein, which leads to an inability to properly excrete acid from the body. This can lead to a buildup of acid in the blood, which can cause a variety of symptoms, including fatigue, muscle weakness, and kidney stones.

The symptoms of Autosomal dominant proximal renal tubular acidosis (dRTA) include:

-Growth failure
-Failure to thrive
-Dehydration
-Vomiting
-Diarrhea
-Metabolic acidosis
-Hypokalemia
-Hypercalciuria
-Hyperphosphaturia
-Renal tubular acidosis
-Renal Fanconi syndrome
-Renal tubular dysfunction
-Renal tubular acidosis
-Renal tubular reabsorption defects
-Renal tubular transport defects
-Renal tubular dysfunction
-Renal tubular acidosis
-Renal tubular reabsorption defects
-Renal tubular transport defects
-Renal tubular dysfunction
-Renal tubular acidosis
-Renal tubular

The causes of Autosomal dominant proximal renal tubular acidosis (ADRTA) are not fully understood. However, it is believed to be caused by mutations in genes that are involved in the regulation of acid-base balance in the kidneys. These mutations can be inherited from a parent or can occur spontaneously. Some of the genes that have been linked to ADRTA include SLC4A4, SLC4A5, SLC4A7, and SLC4A8.

1. Dietary modifications: A diet low in sodium and high in potassium and bicarbonate can help reduce the symptoms of Autosomal dominant proximal renal tubular acidosis.

2. Medications: Medications such as sodium bicarbonate, potassium citrate, and thiazide diuretics can help reduce the acidity of the urine and reduce the symptoms of Autosomal dominant proximal renal tubular acidosis.

3. Dialysis: In some cases, dialysis may be necessary to help remove excess acid from the body.

4. Surgery: In some cases, surgery may be necessary to correct any structural abnormalities in the kidneys.

1. Genetic mutations in the SLC4A1 gene
2. Family history of Autosomal dominant proximal renal tubular acidosis
3. Exposure to certain medications, such as aminoglycosides
4. Exposure to certain toxins, such as lead
5. Certain medical conditions, such as diabetes or chronic kidney disease

Yes, there is a cure for Autosomal dominant proximal renal tubular acidosis. Treatment typically involves medications such as sodium bicarbonate, potassium citrate, and thiazide diuretics. These medications help to reduce the amount of acid in the urine and help to restore the balance of electrolytes in the body. Additionally, dietary changes may be recommended to help reduce the amount of acid in the urine.