Autosomal dominant progressive nephropathy with hypertension is a rare genetic disorder that affects the kidneys. It is characterized by progressive kidney damage, high blood pressure, and proteinuria (excess protein in the urine). It is caused by a mutation in the gene that codes for the protein nephrin, which is involved in the formation of the glomerular filtration barrier in the kidneys. Treatment typically involves controlling blood pressure and managing any complications that arise from the disorder.

The symptoms of Autosomal dominant progressive nephropathy with hypertension include:

-High blood pressure
-Proteinuria (excess protein in the urine)
-Edema (swelling of the feet, ankles, and legs)
-Fatigue
-Headaches
-Nausea
-Vomiting
-Loss of appetite
-Weight loss
-Itching
-Muscle cramps
-Decreased urine output
-Dark-colored urine
-Foamy urine
-Blood in the urine
-Decreased kidney function
-Kidney failure

The exact cause of Autosomal dominant progressive nephropathy with hypertension is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in certain genes that are involved in the regulation of blood pressure and kidney function. Environmental factors may include high salt intake, obesity, and smoking.

1. Blood pressure control: This is the most important treatment for Autosomal dominant progressive nephropathy with hypertension. It is important to keep blood pressure under control to prevent further damage to the kidneys.

2. Medications: Medications such as ACE inhibitors, angiotensin receptor blockers, and diuretics can be used to help control blood pressure and reduce the amount of fluid in the body.

3. Diet: A low-salt, low-protein diet can help reduce the amount of waste products in the blood and reduce the strain on the kidneys.

4. Dialysis: In some cases, dialysis may be necessary to help filter waste products from the blood.

5. Kidney transplant: In some cases, a kidney transplant may be necessary to replace the damaged kidneys.

1. Family history of Autosomal dominant progressive nephropathy with hypertension
2. Age (older age increases risk)
3. Hypertension
4. Diabetes
5. Obesity
6. Smoking
7. High cholesterol
8. High salt intake
9. Excessive alcohol consumption
10. Kidney stones

There is no cure for autosomal dominant progressive nephropathy with hypertension, but medications can be used to help manage the symptoms. These medications may include angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, and calcium channel blockers. Additionally, lifestyle modifications such as reducing salt intake, maintaining a healthy weight, and exercising regularly can help to reduce the risk of complications associated with this condition.