Autoimmune Polyendocrine Syndrome Type II (APS-II) is a rare, inherited disorder that affects the endocrine system. It is characterized by the presence of two or more autoimmune diseases, such as Addison's disease, hypoparathyroidism, and/or type 1 diabetes. People with APS-II may also have other autoimmune diseases, such as vitiligo, alopecia, and pernicious anemia. Symptoms of APS-II can vary, but may include fatigue, weight loss, muscle weakness, and low blood sugar. Treatment typically involves managing the individual autoimmune diseases and may include hormone replacement therapy, immunosuppressive medications, and lifestyle modifications.