Atrial septal defect-atrioventricular conduction defects syndrome (ASD-AVCD) is a rare genetic disorder characterized by a combination of two heart defects: an atrial septal defect (ASD) and an atrioventricular conduction defect (AVCD). An ASD is a hole in the wall between the two upper chambers of the heart (the atria), while an AVCD is a problem with the electrical signals that control the heart's rhythm. People with ASD-AVCD may experience symptoms such as shortness of breath, fatigue, palpitations, and chest pain. Treatment typically involves medications and/or surgery to repair the ASD and/or AVCD.

The symptoms of Atrial septal defect-atrioventricular conduction defects syndrome can vary depending on the severity of the defect. Common symptoms include:

• Shortness of breath
• Fatigue
• Palpitations
• Chest pain
• Swelling of the legs, feet, and abdomen
• Heart murmur
• Poor growth
• Poor feeding
• Poor weight gain
• Poor exercise tolerance
• Abnormal heart rhythms (arrhythmias)
• Heart failure

Atrial septal defect-atrioventricular conduction defects syndrome is caused by a genetic mutation in the GATA4 gene. This gene is responsible for the development of the heart and its electrical conduction system. Mutations in this gene can lead to abnormal development of the heart and its electrical conduction system, resulting in atrial septal defect and atrioventricular conduction defects.

1. Surgery: Open-heart surgery is the most common treatment for atrial septal defect-atrioventricular conduction defects syndrome. During the procedure, the surgeon will repair the hole in the septum and repair any damaged heart tissue.

2. Medication: Medications such as diuretics, ACE inhibitors, and beta-blockers may be prescribed to help manage symptoms and reduce the risk of complications.

3. Pacemaker: A pacemaker may be implanted to help regulate the heart rate and improve the coordination of the heart's chambers.

4. Catheterization: A catheter may be used to close the hole in the septum. This procedure is less invasive than open-heart surgery and may be an option for some patients.

1. Family history of congenital heart defects
2. Maternal diabetes
3. Maternal use of certain medications during pregnancy
4. Maternal exposure to certain environmental toxins
5. Maternal age over 35
6. Low birth weight
7. Premature birth
8. Chromosomal abnormalities

Atrial septal defect-atrioventricular conduction defects syndrome is a complex condition that requires a combination of treatments. Treatment options may include medications to control the heart rate, surgery to repair the defect, and lifestyle changes to reduce the risk of complications. Medications used to treat this condition may include beta-blockers, calcium channel blockers, and antiarrhythmic drugs. Surgery may be recommended to repair the defect and restore normal blood flow. Lifestyle changes such as avoiding alcohol and caffeine, eating a healthy diet, and exercising regularly can also help reduce the risk of complications.