Apparent mineralocorticoid excess (AME) is a rare genetic disorder that affects the body's ability to regulate salt and water balance. It is caused by a mutation in the gene that codes for the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2). This enzyme normally helps to convert cortisol, a hormone produced by the adrenal glands, into cortisone, which is inactive. In people with AME, the enzyme does not work properly, leading to an excess of cortisol in the body. This can cause a variety of symptoms, including high blood pressure, low potassium levels, and excessive thirst and urination. Treatment for AME typically involves medications to reduce cortisol levels and to help regulate salt and water balance.