The treatments for AP-4-Associated Hereditary Spastic Paraplegia (AP-4-HSP) are mainly supportive and symptomatic. Physical therapy, occupational therapy, and speech therapy can help to improve mobility, coordination, and communication. Orthopedic devices such as braces, walkers, and wheelchairs can also be used to improve mobility. Medications such as baclofen, diazepam, and tizanidine can be used to reduce spasticity. Botulinum toxin injections can also be used to reduce spasticity in specific muscles. Surgery may be recommended in some cases to release tight muscles or to correct deformities.