Anterior maxillary protrusion-strabismus-intellectual disability syndrome is a rare genetic disorder characterized by a protrusion of the upper jaw, strabismus (crossed eyes), and intellectual disability. It is caused by a mutation in the GNAI3 gene, which is responsible for the development of the face and eyes. Symptoms may also include a wide nasal bridge, a long face, and a wide mouth. Treatment typically involves orthodontic braces to correct the protrusion of the upper jaw, and surgery to correct the strabismus.

The symptoms of Anterior Maxillary Protrusion-Strabismus-Intellectual disability Syndrome (AMP-SID) include:

• Anterior maxillary protrusion (protruding upper jaw)
• Strabismus (crossed eyes)
• Intellectual disability
• Delayed development
• Poor coordination
• Speech and language delays
• Abnormal facial features
• Abnormalities of the hands and feet
• Abnormalities of the teeth
• Abnormalities of the eyes
• Abnormalities of the ears
• Abnormalities of the heart
• Abnormalities of the kidneys
• Abnormalities of the gastrointestinal tract
• Abnormalities of the skin

Anterior maxillary protrusion-strabismus-intellectual disability syndrome is a rare genetic disorder caused by a mutation in the GNAI3 gene. This gene is responsible for the production of a protein that helps regulate the development of the face and eyes. Mutations in this gene can lead to a variety of physical and cognitive abnormalities, including an anterior maxillary protrusion, strabismus, and intellectual disability. Other associated features may include cleft lip and palate, hearing loss, and seizures.

There is no known cure for Anterior Maxillary Protrusion-Strabismus-Intellectual Disability Syndrome. Treatment focuses on managing the symptoms and providing support to the individual and their family. Treatment may include:

• Orthodontic treatment to correct the malocclusion and improve the facial appearance.

• Surgery to correct the strabismus.

• Speech therapy to improve communication skills.

• Physical therapy to improve mobility and coordination.

• Occupational therapy to help with daily activities.

• Behavioral therapy to help with social skills and emotional regulation.

• Special education services to help with learning.

• Nutritional counseling to ensure proper nutrition.

• Medication to help with any associated medical conditions.

1. Genetic mutation: Anterior maxillary protrusion-strabismus-intellectual disability syndrome is caused by a mutation in the GPR143 gene.

2. Family history: Individuals with a family history of the disorder are at an increased risk of developing the condition.

3. Age: The condition is more common in children and adolescents.

4. Gender: Females are more likely to be affected than males.

5. Ethnicity: The disorder is more common in individuals of Asian descent.

Unfortunately, there is no known cure for Anterior Maxillary Protrusion-Strabismus-Intellectual Disability Syndrome. However, there are medications that can help manage the symptoms associated with the syndrome. These medications may include muscle relaxants, anticonvulsants, and antipsychotics. Additionally, physical and occupational therapy can help improve motor skills and coordination. Speech therapy can also help improve communication skills.