Antenatal multiminicore disease with arthrogryposis multiplex congenita (AMC-AMC) is a rare genetic disorder that affects the development of the muscles and joints. It is characterized by multiple joint contractures (arthrogryposis) and a reduction in the number of muscle fibers (multiminicore). AMC-AMC is caused by a mutation in the SEPN1 gene, which is responsible for the production of a protein that helps to maintain the structure of muscle fibers. Symptoms of AMC-AMC can include joint stiffness, muscle weakness, and difficulty with movement. Treatment typically involves physical and occupational therapy to help improve range of motion and strength.

The symptoms of antenatal multiminicore disease with arthrogryposis multiplex congenita can vary from person to person, but may include:

-Muscle Weakness and/or hypotonia
Contractures of the joints
-Joint deformities
-Abnormal curvature of the spine (scoliosis)
-Abnormal facial features
-Feeding difficulties
-Respiratory problems
-Developmental delays
-Seizures
-Hearing and vision problems
-Heart defects
-Kidney abnormalities
-Gastrointestinal problems

The exact cause of antenatal multiminicore disease with arthrogryposis multiplex congenita (AMC) is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in certain genes, such as the RYR1 gene, which is involved in muscle development. Environmental factors may include exposure to certain toxins or infections during pregnancy.

Treatment for antenatal multiminicore disease with arthrogryposis multiplex congenita (AMC) is focused on managing the symptoms and complications associated with the condition. Treatment may include physical therapy, occupational therapy, orthopedic surgery, and bracing. Physical therapy can help improve range of motion, strength, and coordination. Occupational therapy can help with activities of daily living, such as dressing, eating, and bathing. Orthopedic surgery may be necessary to correct joint deformities and improve range of motion. Bracing may be used to help support weakened muscles and joints. In some cases, medications may be prescribed to help manage muscle spasms.

1. Maternal diabetes
2. Maternal advanced age
3. Maternal obesity
4. Maternal smoking
5. Maternal alcohol consumption
6. Maternal exposure to certain medications or toxins
7. Maternal infection
8. Family history of neuromuscular disorders
9. Genetic mutations or chromosomal abnormalities
10. Abnormalities in the placenta or umbilical cord

At this time, there is no cure for antenatal multiminicore disease with arthrogryposis multiplex congenita. Treatment focuses on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, orthopedic surgery, and medications to help manage muscle spasms and pain.