Anoctamin-5-related limb-girdle muscular dystrophy R12 is a rare, inherited disorder that affects the muscles. It is caused by mutations in the ANO5 gene, which is responsible for producing anoctamin-5, a protein involved in muscle contraction. Symptoms of this disorder include muscle weakness and wasting, especially in the hips and shoulders, as well as difficulty walking and breathing. In some cases, the disorder can also cause heart problems. There is currently no cure for this disorder, but physical therapy and other treatments can help manage symptoms.