Ankyloblepharon filiforme adnatum-imperforate anus syndrome (AFA-IA) is a rare genetic disorder characterized by the fusion of the eyelids, imperforate anus, and other physical anomalies. It is caused by a mutation in the TP63 gene. Symptoms may include fused eyelids, cleft lip and/or palate, malformed ears, and a variety of other physical anomalies. Affected individuals may also have intellectual disability, developmental delay, and/or behavioral problems. Treatment is based on the individual's symptoms and may include surgery, physical therapy, and/or medications.