Angelman syndrome is a genetic disorder caused by a deletion of a small piece of chromosome 15, or by a mutation in the UBE3A gene located on the same chromosome. It is also caused by paternal uniparental disomy of chromosome 15, which is when both copies of chromosome 15 come from the father instead of one from the mother and one from the father.

The most common symptoms of Angelman syndrome due to paternal uniparental disomy of chromosome 15 include:

-Developmental delay
-Seizures
-Speech impairment
-Movement and balance disorders
-Behavioral problems such as hyperactivity, short attention span, and inappropriate laughter
-Sleep disturbances
-Feeding difficulties
-Microcephaly (Small head size)
-Flat back of the head
-Wide-set eyes
-Wide mouth with full lips
-Small chin
-Tongue protrusion
-Hypopigmentation (light skin and hair color)

1. Imprinting defect: Angelman syndrome is caused by a defect in the imprinting process, which is the process by which certain genes are turned on or off depending on which parent they come from. In the case of Angelman syndrome, the gene responsible for the disorder is not expressed because it is inherited from the father's chromosome 15.

2. Mutation: A mutation in the UBE3A gene, located on chromosome 15, is responsible for Angelman syndrome. This gene is normally expressed from the mother's chromosome 15, but in cases of paternal uniparental disomy, the gene is not expressed because it is inherited from the father's chromosome 15.

3. Chromosomal abnormality: Paternal uniparental disomy of chromosome 15 is a chromosomal abnormality in which both copies of chromosome 15 are

1. Early intervention: Early intervention programs, such as physical, occupational, and speech therapy, can help improve the development of children with Angelman syndrome.

2. Medication: Medications such as clonazepam, melatonin, and baclofen may be used to help manage seizures, sleep disturbances, and muscle spasms.

3. Dietary changes: A ketogenic diet may be recommended to help reduce the frequency and severity of seizures.

4. Surgery: Surgery may be recommended to correct certain physical abnormalities, such as scoliosis or hip dysplasia.

5. Genetic counseling: Genetic counseling can help families understand the condition and the risks associated with it.

1. Paternal uniparental disomy of chromosome 15
2. Maternal age over 35
3. Family history of Angelman syndrome
4. Advanced paternal age
5. Maternal meiotic errors
6. Maternal UPD of chromosome 15
7. Maternal imprinting defects
8. Maternal uniparental heterodisomy of chromosome 15
9. Maternal duplication of chromosome 15
10. Maternal translocation involving chromosome 15

At this time, there is no cure for Angelman syndrome due to paternal uniparental disomy of chromosome 15. However, there are medications and therapies that can help manage the symptoms of the disorder. These include medications to help with seizures, physical and occupational therapy to help with motor skills, speech therapy to help with communication, and behavior therapy to help with social skills.