Angelman syndrome is a genetic disorder caused by a deletion of a small piece of chromosome 15 in the region known as 15q11-q13. This deletion is usually inherited from the mother. The deletion results in the loss of several genes, which can lead to a wide range of physical and mental disabilities. Symptoms of Angelman syndrome include developmental delays, intellectual disability, seizures, sleep disturbances, and movement and balance problems.

The most common symptoms of Angelman syndrome due to maternal 15q11q13 deletion include:

-Developmental delay
-Seizures
-Speech impairment
-Movement and balance disorders
-Behavioral problems such as hyperactivity, short attention span, and sleep disturbances
-Frequent laughter or smiling
-Facial features such as a wide mouth, protruding tongue, and small head
-Feeding difficulties
-Weak muscle tone

Angelman syndrome is caused by a deletion of a small piece of chromosome 15 in the region known as 15q11-q13. This deletion occurs in the mother's egg or sperm before conception. It is not inherited from either parent. The exact cause of the deletion is unknown, but it is thought to be due to a combination of genetic and environmental factors.

1. Physical therapy: Physical therapy can help improve muscle tone, balance, coordination, and motor skills.

2. Occupational therapy: Occupational therapy can help improve fine motor skills, self-care skills, and communication.

3. Speech therapy: Speech therapy can help improve communication and language skills.

4. Behavioral therapy: Behavioral therapy can help improve social skills, reduce challenging behaviors, and increase independence.

5. Medications: Medications can help reduce seizures and improve sleep.

6. Dietary changes: Dietary changes can help improve nutrition and reduce symptoms.

7. Surgery: Surgery can help improve mobility and reduce seizures.

1. Maternal age over 35
2. Maternal history of infertility
3. Maternal history of recurrent miscarriages
4. Maternal history of advanced maternal age pregnancies
5. Maternal history of consanguinity
6. Maternal history of advanced paternal age
7. Maternal history of exposure to environmental toxins
8. Maternal history of exposure to certain medications
9. Maternal history of exposure to radiation
10. Maternal history of advanced paternal age pregnancies
11. Maternal history of advanced maternal age pregnancies with a male fetus
12. Maternal history of advanced paternal age pregnancies with a female fetus
13. Maternal history of advanced paternal age pregnancies with a male fetus and a female fetus
14. Maternal history of advanced maternal age pregnancies with a male fetus and a female fetus
15. Maternal history of

At this time, there is no cure for Angelman syndrome due to a maternal 15q11q13 deletion. However, there are medications and therapies that can help manage the symptoms of the disorder. These include medications to help with seizures, physical and occupational therapy to help with motor skills, speech therapy to help with communication, and behavior therapy to help with social skills.