Angelman syndrome is a genetic disorder caused by a defect in the imprinting process of the 15q11-q13 region of the genome. This region contains several genes that are important for normal brain development. When the imprinting process is disrupted, the genes are not expressed properly, leading to the characteristic features of Angelman syndrome.

The most common symptoms of Angelman syndrome due to imprinting defect in 15q11-q13 include:

-Developmental delay
-Seizures
-Speech impairment
-Movement and balance disorders
-Behavioral problems such as hyperactivity, short attention span, and inappropriate laughter
-Sleep disturbances
-Feeding difficulties
-Microcephaly (Small head size)
-Flat back of the head
-Wide-set eyes
-Fairly normal physical features
-Frequent smiling and laughter

1. Maternal uniparental disomy (UPD) of chromosome 15: This occurs when a person has two copies of chromosome 15 from the mother and none from the father.

2. Deletion of the maternal copy of chromosome 15: This occurs when a portion of the maternal copy of chromosome 15 is missing.

3. Imprinting defect: This occurs when the genetic material from the mother and father is not correctly imprinted, resulting in an abnormal expression of genes on chromosome 15.

4. Mutation in the UBE3A gene: This occurs when there is a mutation in the UBE3A gene, which is located on chromosome 15.

1. Physical therapy: Physical therapy can help improve muscle tone, balance, coordination, and motor skills.

2. Occupational therapy: Occupational therapy can help improve fine motor skills, communication, and daily living skills.

3. Speech therapy: Speech therapy can help improve communication skills.

4. Behavioral therapy: Behavioral therapy can help improve social skills, reduce challenging behaviors, and increase independence.

5. Medications: Medications can help reduce seizures and improve sleep.

6. Dietary modifications: Dietary modifications can help improve nutrition and reduce symptoms.

7. Genetic counseling: Genetic counseling can help families understand the condition and make informed decisions about their child’s care.

1. Maternal age over 35
2. Maternal uniparental disomy (UPD) of chromosome 15
3. Maternal duplication of 15q11-q13
4. Maternal deletion of 15q11-q13
5. Maternal imprinting defect in 15q11-q13
6. Paternal uniparental disomy (UPD) of chromosome 15
7. Paternal duplication of 15q11-q13
8. Paternal deletion of 15q11-q13
9. Paternal imprinting defect in 15q11-q13
10. Maternal or paternal translocation involving 15q11-q13
11. Maternal or paternal inversion involving 15q11-q13
12. Maternal or paternal isodisomy of chromosome 15
13.

At this time, there is no cure for Angelman syndrome due to imprinting defect in 15q11-q13. However, there are medications and therapies that can help manage the symptoms of the disorder. These include medications to help with seizures, physical and occupational therapy to help with motor skills, speech therapy to help with communication, and behavior therapy to help with social skills.