Angel-shaped phalango-epiphyseal dysplasia (APED) is a rare genetic disorder that affects the growth of bones in the hands and feet. It is characterized by short stature, short fingers and toes, and a distinctive angel-shaped appearance of the epiphyses (the ends of the long bones). Other features may include joint stiffness, scoliosis, and hearing loss. APED is caused by a mutation in the gene that codes for the enzyme lysyl hydroxylase-2 (LH2). Treatment is supportive and may include physical therapy, orthopedic surgery, and hearing aids.