Adult-onset autosomal dominant leukodystrophy (ADLD) is a rare, progressive neurological disorder that affects the white matter of the brain. It is caused by a genetic mutation that is passed down from parent to child. Symptoms typically begin in adulthood and include difficulty walking, muscle weakness, vision problems, and cognitive decline. In some cases, the disorder can lead to dementia. Treatment is supportive and may include physical therapy, speech therapy, and medications to manage symptoms.