Acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate (ARLKG) is a rare neurological disorder characterized by the sudden onset of neurological symptoms, including confusion, disorientation, memory loss, and seizures. It is associated with increased levels of alpha-ketoglutarate (AKG) in the urine. The exact cause of ARLKG is unknown, but it is thought to be related to an underlying metabolic disorder. Treatment typically involves supportive care and management of the underlying metabolic disorder.

The symptoms of Acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate (ARLK) can vary from person to person, but may include:

-Headache

-Confusion

-Personality changes

-Seizures

-Loss of coordination

-Difficulty speaking

-Visual disturbances

-Memory loss

-Fatigue

-Nausea

-Vomiting

-Loss of appetite

-Weight loss

-Muscle weakness

-Difficulty walking

-Urinary incontinence

The exact cause of acute reversible leukoencephalopathy with increased urinary alpha-ketoglutarate (ARLK) is unknown. However, it is believed to be caused by an underlying metabolic disorder, such as an inborn error of metabolism, or a genetic mutation. Other potential causes include certain medications, infections, and exposure to toxins.

1. Supportive care: This includes providing adequate hydration, electrolyte balance, and nutrition.

2. Corticosteroids: These can be used to reduce inflammation and improve symptoms.

3. Plasma exchange: This is a procedure in which the patient’s blood is removed and replaced with donor plasma. This can help reduce the levels of toxins in the blood.

4. Immunosuppressive therapy: This involves using medications to suppress the immune system and reduce inflammation.

5. Intravenous immunoglobulin (IVIG): This is a treatment that involves infusing antibodies into the bloodstream to help reduce inflammation.

6. Antiviral medications: These can be used to treat any underlying viral infections that may be contributing to the condition.

1. Recent chemotherapy or radiation therapy
2. Recent infection
3. Recent surgery
4. Recent organ transplant
5. Recent high-dose corticosteroid use
6. Recent high-dose nonsteroidal anti-inflammatory drug use
7. Recent high-dose anticonvulsant use
8. Recent high-dose immunosuppressant use
9. Recent high-dose antibiotic use
10. Recent high-dose antifungal use
11. Recent high-dose antiviral use
12. Recent high-dose antineoplastic use
13. Recent high-dose antiretroviral use
14. Recent high-dose antimalarial use
15. Recent high-dose antiparasitic use
16. Recent high-dose anti-inflammatory use
17. Recent high-dose ant

At this time, there is no known cure for Acute Reversible Leukoencephalopathy with Increased Urinary Alpha-Ketoglutarate (ARLK). Treatment is focused on managing the symptoms and preventing further damage to the brain. Medications such as corticosteroids, immunosuppressants, and anticonvulsants may be used to reduce inflammation and control seizures. Other treatments such as physical therapy, occupational therapy, and speech therapy may also be recommended to help improve motor and cognitive function.