1. Age: Acute necrotizing encephalopathy of childhood (ANEC) typically affects children between the ages of 1 and 4 years old.
2. Viral infection: ANEC is often preceded by a viral infection, such as influenza, herpes simplex virus, or enterovirus.
3. Immunodeficiency: Children with weakened immune systems are more likely to develop ANEC.
4. Genetic predisposition: Certain genetic mutations have been linked to an increased risk of ANEC.
5. Exposure to toxins: Exposure to certain toxins, such as carbon monoxide, can increase the risk of ANEC.