Acute graft versus host disease (aGVHD) is a serious complication that can occur after a stem cell or bone marrow transplant. It occurs when the donor cells (the graft) attack the recipient’s (the host’s) organs and tissues. Symptoms of aGVHD can include skin rash, diarrhea, nausea, vomiting, abdominal pain, and liver and/or kidney failure. Treatment for aGVHD may include immunosuppressive medications, transfusions, and supportive care.

The symptoms of acute graft versus host disease (GVHD) can vary depending on the organs affected, but may include:

- Skin rash or itching
- Diarrhea
- Nausea and vomiting
- Abdominal pain
- Fatigue
- Joint pain
- Fever
- Weight loss
- Jaundice
- Liver and/or spleen enlargement
- Shortness of breath
- Mouth sores
- Hair loss

1. An incompatible donor-recipient match
2. A high dose of donor cells
3. A weakened immune system
4. An infection
5. Certain medications
6. Radiation therapy
7. A history of GVHD in the past

1. Corticosteroids: These are the most commonly used drugs to treat acute GVHD. They work by suppressing the immune system and reducing inflammation.

2. Immunosuppressants: These drugs work by suppressing the immune system and reducing inflammation. Examples include cyclosporine, tacrolimus, and mycophenolate mofetil.

3. Antibiotics: These are used to treat bacterial infections that can occur as a result of GVHD.

4. Intravenous immunoglobulin (IVIG): This is a blood product that contains antibodies from healthy donors. It can help reduce inflammation and improve symptoms of GVHD.

5. Photopheresis: This is a procedure in which a patient’s blood is exposed to ultraviolet light and then re-inf

1. High intensity of the donor’s T-cells
2. Older age of the recipient
3. Female gender of the recipient
4. Higher doses of immunosuppressive drugs
5. Presence of chronic GVHD
6. Presence of HLA mismatch between donor and recipient
7. Presence of infections
8. Presence of pre-existing organ dysfunction
9. Presence of acute GVHD prior to transplant
10. Presence of certain genetic polymorphisms

Yes, there are medications and treatments available for acute graft versus host disease (GVHD). These include corticosteroids, calcineurin inhibitors, mycophenolate mofetil, and other immunosuppressive drugs. Additionally, supportive care such as nutrition, hydration, and antibiotics may be necessary. In some cases, stem cell transplantation may be necessary to treat GVHD.