The treatments for Activated PI3K-delta syndrome vary depending on the individual and the severity of the condition. Generally, treatments may include medications to reduce inflammation, physical therapy, occupational therapy, speech therapy, and surgery. Medications may include non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressants. Physical therapy may help improve mobility and strength, while occupational therapy can help with activities of daily living. Speech therapy may help with communication and swallowing difficulties. Surgery may be necessary to correct physical deformities or to remove tumors.